Subunit Interactions & the Mechanism of Allosteric Regulation

            Background Information to the project area

 Current Focus:

                        Watermelon Glyoxysomal Malate Dehydrogenase

                        Plasmodium falciparum Malate Dehydrogenase

 Schools Teaching CUREs based on this project areas

                        University of San Diego

                        St John Fisher College

 Available Biologics

                        wt Watermelon Glyoxysomal Malate Dehydrogenase

                        Interface mutants of Watermelon Glyoxysomal Malate Dehydrogenase

                        wt Plasmodium falciparum Malate Dehydrogenase

 Publications

Exploring Active Site Communication in Malate Dehydrogenase: The Role of First and Second Sphere Residues, Sharon Shani, Ellis Bell, Jessica Bell. First published: 18 April 2020:

Exploring Subunit Communication of Malate Dehydrogenase through Interface Point‐ Mutations, Michael Schwabe, Sharon Shania, Nina Marie Garcia, Sasha Graham, Ellis Bell: First published: 01 April 2018,

The Role of Methionine Residues in Activity and Subunit Communication in Malate Dehydrogenase, Farren Billue, Ellis Bell, First published: 01 April 2010,

Probing the Subunit Interface of Malate Dehydrogenase: Effects of S266A and L269A Mutations, Nikia James, Jayme Verdi, Ellis Bell, Jessica Bell: First published: 01 April 2016,

Engineering Cysteine Residues into Glyoxysomal Malate Dehydrogenase to Study Subunit Interactions Using Fluorescence and AFM, Mary Jane Drake, Ellis Bell: First published: 01 April 2011,

The Effects of the H90 and E256 Mutations in the gMDH Interface on the Stability, Function, and Interface Interactions of gMDH, Zachary Stewart, Nina Marie Garcia, Ellis Bell, Jessica Bell, First published: 01 April 2016,